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MOTOR IMPROVEMENT BY ELECTRICAL STIMULATION OR MK-801 MICROINJECTION INTO THE INFERIOR COLLICULUS IN PARKINSONIAN MICE
Autores:
LIANA MELO-THOMAS, ANA LUISA GIL MARTINEZ,
CRISTINA ESTRADA ESTEBAN
, LORENA CUENCA, ANA GONZALEZ CUELLO, FRANCISCO JOSÉ FERNANDEZ GOMEZ, EMILIANO FERNANDEZ VILLALBA, RAINER SCHWARTING,
MARIA TRINIDAD HERRERO EZQUERRO
,
Grupos de investigación:
[GI/IMIB/C043/2011] Neurociencia Clínica y Experimental
Comunicación:
Antecedentes:
The inferior colliculus (IC) is an important midbrain relay station for the integration of descending and ascending auditory information. Additionnally, IC has also been implicated in processing sensory-motor responses as demonstrated in haloperidol-induced catalepsy animal model, increasing motor activity by intracollicular microinjections glutamate receptor antagonists (MK-801).
Métodos:
The present study aimed to investigate the effects of either unilateral intracollicular electrical stimulation or unilateral MK-801 (6 nmol/0.1?L) microinjection in young (9 m.o.) and old (22 m.o.) mice (C57BL/6 strain) chronically treated with saline or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 6.8 mg/kg/month during 6 months). After electrical stimulation or microinjections the mice were submitted to rotarod and actimetry tests, respectively.
Resultados:
Old MPTP-treated mice increased the time spent on the rotarod (F3,11=6.47, p<0.05) after 10 min, 20 min and 24 h intracollicular electrical stimulation, whereas that the sham stimulation procedure did not influence the time spent on the rotarod (F3,11=0.52; p>0.05). After unilateral microinjection of MK-801, old MPTP-treated mice increased the distance travelled in the actimetry test (F3,45=5.175; p<0.05).
Conclusiones:
Intracollicular electrical stimulation or MK-801 microinjection improve the motor performance in old-Parkinsonian mice suggesting IC as a new therapeutic non-conventional target in motor impairment.
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