Esta web utiliza cookies. Si continúas navegando consideramos que aceptas su uso.
Más información
Aceptar
I Jornadas Científicas del IMIB-Arrixaca
Acceso Personal
Contacto
Aviso Legal
Inicio
Bienvenida
Comités
Ponencias
Comunicaciones
Programa
Fechas clave
Inscripciones
Selección comunicaciones
Enviar comunicación
Patrocinadores
Sede
Imprimir
GASTROINTESTINAL MUCOUS INJURY EXACERBATES INFLAMMATION IN PARKINSONIAN MICE
Autores:
ANA LUISA GIL MARTINEZ,
CRISTINA ESTRADA ESTEBAN
, JOSE ANTONIO CANO, MANUEL VALIENTE, ANA GONZALEZ CUELLO, EMILIANO FERNANDEZ VILLALBA,
MARIA TRINIDAD HERRERO EZQUERRO
,
Grupos de investigación:
[GI/IMIB/C043/2011] Neurociencia Clínica y Experimental
Comunicación:
Antecedentes:
Systemic inflammation has an important role in the development of degenerative diseases such as Alzheimer’s or Parkinson’s diseases. The aim of the present study was to investigate the relationship between specific inflammatory processes in the digestive tract and its impact on the inflammation that occurs in the Substantia Nigra pars compacta (SNpc) in Parkinsonism.
Métodos:
To ascertain this possibility, we used the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model in 48 three-months-old mice (C57BL/6 strain) with or without ulcerative colitis induced by the ad libitum ingestion of dextran sulphate sodium (DSS). Midbrain cells were quantitatively evaluated in postmortem studies marked by immunohistochemistry techniques: i) dopaminergic neurons evidenced by tyrosine hydroxylase (TH); and ii) the number of microglial cells evidenced by the specific binding microglial calcium protein (Iba-1).
Resultados:
We found a significant increase in microglial activation in both the MPTP and in the DSS groups but being significantly increased in MPTP+DSS-treated animals compared to the other groups
Conclusiones:
These results suggest that gastrointestinal mucous injury, as specific increased peripheral inflammation, plays an additional role in microglia activation in SNpc in Parkinsonism, supporting the hypothesis of possible deleterious interaction of the gut-brain axis in Parkinson’s disease.
Instituto de Investigación Sanitaria Acreditado
Inicio
Grupo de Investigación
Miembros
Proyectos
Colaboraciones
Servicios
Recursos formativos
Producción Científica
Publicaciones
Tesis
Novedades
Noticias
Eventos
Convocatorias
Agenda