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PLURIPOTENT CELLS ISOLATED FROM THE RETINAL CILIARY BODY ATTENUATE AXOTOMY-INDUCED RETINAL GANGLION CELL DEATH
Autores:
FERNANDO LUCAS RUIZ
, VIOLETA GÓMEZ VICENTE,
FRANCISCO JAVIER VALIENTE SORIANO
,
FRANCISCO MANUEL NADAL NICOLAS
, MARTA FERNÁNDEZ NOGALES, ELOISA HERRERA GONZÁLEZ DE MOLINA,
MARTA AGUDO BARRIUSO
,
Grupos de investigación:
[GI/IMIB/C004/2011] Oftalmología Experimental
Comunicación:
Antecedentes:
Ciliary body cells (CBCs) obtained from adult retinas have the capacity to give rise to different retinal cell types in vitro. To investigate the therapeutic potential of these cells in retinodegenerative diseases, we have assessed the effect of these pluripotent cells on the survival of retinal ganglion cells (RGCs) after injury.
Métodos:
CBCs were isolated from C57/Bl6 adult mice and intravitreally injected into the retinas of mice axotomized by optic nerve crush or into intact control retinas. Vehicle was used in matched groups as an additional control (n=6-10/group). Axotomized and control retinas were collected at different time points after the injection and RGCs were immunoidentified and quantified.
Resultados:
CBCs are not toxic for RGCs, nor they divide or form tumors, as observed in non-axotomized retinas. Compared to vehicle, transplanted CBCs increased the survival of RGCs at all time points, being the beneficial effect more apparent at longer time periods (22% at 3 days and 83% at 14 days).
Conclusiones:
CBCs exert a neuroprotective effect on injured RGCs, and they are more effective after the first wave of RGC death.
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